A series of coumarin Schiff bases, (E)-N’arylidine-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)-acetohydrazides (IVa-m) were synthesized by the reaction of intermediate, acetohydrazide of coumarin(III) with different aryl/hetero aromatic aldehydes in chloroform:methanol (1:1) mixture, in presence of glacial acetic acid and characterized by IR, NMR and Mass spectral data. The title compounds were evaluated for in-vitro antitubercular activity against Mycobacterium tuberculosis H37Rv by almar blue dye method and in-vitro antimicrobial activity against bacterial strains by serial dilution method. All the compounds exhibited moderate to weak antitubercular activity and compound IVe with 1, 2-dioxymethylene substitution on phenyl ring exhibited excellent antibacterial activity and compound IVh with p-nitro substitution on phenyl ring exhibited good antibacterial activity while other compounds displayed moderate to weak antibacterial activity against Gram positive bacteria S. aureus when compared with standard drug. None of the compounds were able to exhibit the antibacterial activity against Gram negative bacteria E. coli with MIC value of 100 µg/ml or more. In conclusion, our study has successfully identified potent antibacterial activity of coumarin schiff bases.
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